I once had an idea about a hypochondriac robot and a manic monkey/dog (a genetic-hybrid) who travel the galaxy selling useless products to aliens. Like door to door salesmen. Their space ship is the size of a small country but most of the interior is filled with cargo, so these two live in a cramped little command module. There is a lot of travel time from A to B in outer space so there’s plenty of time for these guys to really drive each other crazy in there.
I’ve always been a sucker for cartoon science fiction stuff, but this idea is really about sharing space with someone… Sharing a bedroom with your little brother or a cubicle with someone at work. It was inspired by staying in an apartment full of guys and the frictions that result from having room-mates; all those little annoying brouhahas over who ate who’s stuff in the fridge and so on. Just put all that button-pushing and passive aggressive shenanigans “IN SPACE” with robots and monkey/dogs and there you go. Sort of a Silent Running GlenGarry GlenRoss Odd Couple Ice Station Zebra type thang… for kids!